Felson / Schaible Pain in Osteoarthritis

1. Auflage 2010
ISBN: 978-0-470-93055-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 320 Seiten, E-Book

An authoritative investigation of the sources andtreatment ofosteoarthritic joint pain
Millions of people throughout the world suffer fromosteoarthritis (OA)--a medical condition causing its sufferersexcruciating pain that is often disabling. This is the first bookto offer clinicians an in-depth understanding of the biologicalsources of osteoarthritic pain and how they can be treated. Here, ateam of leading international authorities has contributedstate-of-the-art information on:
* The Neuroscience of Articular Pain--spinal and peripheralmechanisms of joint pain; experimental models for the study ofosteoarthritic pain; inflammatory mediators and nociception inarthritis; phantoms in rheumatology; and more
* Osteoarthritis and Pain--joint mechanisms and neuromuscularaspects of OA; bone pain and pressure in OA joints; structuralcorrelates of OA pain; and more
* Treatment of Osteoarthritic Pain--general approaches totreatment; treatments targeting pain receptors; treatmentstargeting biomechanical abnormalities; and treatments targetinginflammation
Whether you're a medical professional, researcher, student, or ageneralist or specialist focusing on pain or arthritis, this isyour one-stop reference for understanding and treating joint painin osteoarthritis.

Autoren/Hrsg.

Felson, David T.

Schaible, Hans-Georg

Inhaltsverzeichnis

Preface.
Acknowledgments.
Contributors.
PART I: THE NEUROSCIENCE OF ARTICULAR PAIN.
1. Spinal Mechanisms Contributing to Joint Pain (Hans-GeorgSchaible).
2. Activation of Sensory Neurons in the Arthritic Joint (BlairD. Grubb).
3. Changes in the Neural Substrate of Nociception in a RatDerangement Model of Osteoarthritis (James L. Henry).
4. Inflammatory Mediators and Nociception in Osteoarthritis(Bruce L. Kidd, Jason J. McDougall, and Julia J. Inglis).
5. Phantoms in Rheumatology (Candida S. McCabe, Richard C.Haigh, Nicholas G. Shenker, Jenny Lewis, and David R. Blake).
6. Mechanisms That Generate and Maintain Bone Cancer Pain (JuanMiguel Jimenez-Andrade, Monica Herrera, and Patrick W. Mantyh).
7. Symmetry, T-Cells, and Neurogenic Arthritis (Nicholas G.Shenker, David R. Blake, Candida S. McCabe, Richard C. Haigh, andPaul I. Mapp).
PART II: OSTEOARTHRITIS AND PAIN.
8. Joint Mechanics in Osteoarthritis (Walter Herzog, DouglasBourne, and Aliaa Rehan Youssef).
9. Neuromuscular Aspects of Osteoarthritis (Kenneth D.Brandt).
10. Pressure-Driven Intravasation of Osseous Fat in thePathogenesis of Osteoarthritic Pain (Peer A. Simkin).
11. Structural Correlates of Osteoarthritis Pain: Lessons FromMagnetic Resonance Imaging (Philip G. Conaghan).
12. Evidence of Sensitization to pain in Human Osteoarthritis(Gunnar Ordeberg).
13. Current Perspectives on the Clinical Presentation of JointPain in Human Osteoarthritis (Paul Creamer).
PART III: TREATMENT OF OSTEOARTHRITIC PAIN.
14. General Approach to treating Osteoarthritic Pain: TargetingBiomechanics Inflammation and Nociception (David T. Felson).
15. Neurobiological Mechanisms of Osteoarthritic Pain andAnalgesic treatment (Tuhina Neogi and Joachim Scholz).
16. Exercise, Taping, and Bracing as Treatments for KneeOsteoarthritis Pain (Kim Louise Bennell, Michael Anthony Hunt, andRana Shane Hinman).
17. Treating Inflammation to Relieve Osteoarthritic Pain (DavidT. Felson).
Index.

Über Autor(innen)

David T. Felson, Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA.

Hans-Georg Schaible, Institute of Physiology, University Hospital of Jena, Jena, Germany.