Komoda The HDL Handbook

Biological Functions and Clinical Implications
1. Auflage 2010
ISBN: 978-0-12-382172-0
Verlag: Elsevier Reference Monographs
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 296 Seiten

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.
Comprehensive coverage of basic science, genetics, epidemiology and treatment Reputable content on latest advances in HDL cholesterol research Inclusive, worldwide content with country specific information In depth discussion of potential targets to modify HDL

Autoren/Hrsg.

Komoda, Tsugikazu

Inhaltsverzeichnis

1;Front Cover
;1
2;The HDL Handbook;4
3;Copyright
;5
4;Contents;6
5;Preface;8
6;Contributors;10
7;Chapter 1
Role of Phospholipid Transfer Protein in HDL Remodeling and Atherosclerosis;14
7.1;Introduction;14
7.2;Molecular biology and structure of phospholipid transfer protein;15
7.3;PLTP-mediated lipid transfer;17
7.4;PLTP-mediated HDL remodeling;17
7.5;Genetically modified animals;18
7.6;PLTP and atherosclerosis in humans;22
7.7;Conclusion;23
7.8;References;23
8;Chapter 2
The Role of Cholesteryl Ester Transfer Protein (CETP) in HDL Metabolism;30
8.1;Introduction;30
8.2;Molecular biology;31
8.3;Effect of CETP action on HDL structure;33
8.4;Effect of CETP activity on plasma HDL levels and atherosclerotic disease;33
8.5;Effect of CETP activity on HDL function and consequences for atherosclerotic disease;35
8.6;Polymorphisms of the CETP gene and interactions between environmental influences and HDL;39
8.7;Inhibitors of CETP activity as therapy;40
8.8;Conclusion;41
8.9;References;41
9;Chapter 3
Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology;48
9.1;Introduction;48
9.2;Structure of CETP;50
9.3;Regulation of CETP expression;50
9.4;Function of CETP;51
9.5;Role of CETP in apoE-rich HDL formation;54
9.6;Molecular genetics and the ethnic difference in the frequency of human CETP deficiency;55
9.7;Clinical chemistry of LDL-cholesterol and HDL-cholesterol in CETP deficiency;56
9.8;Epidemiology of increased HDL cholesterol levels and CETP deficiency;57
9.9;Development of a CETP inhibitor;59
9.10;Role of CETP in aging and longevity;61
9.11;Role of CETP in dyslipidemia associated with diabetes and metabolic syndrome;63
9.12;Clinical Trials of CETP inhibitors;64
9.13;Low CETP status, genetic or environmental?;64
9.14;References;64
10;Chapter 4
HDL and Reverse Cholesterol Transport: Physiological Modulation;74
10.1;Influence of aging on the reverse cholesterol transport pathway;74
10.2;Influence of hormones on the reverse cholesterol transport pathway;74
10.3;Influence of physical activity on the reverse cholesterol transport pathway;78
10.4;Influence of diet on the reverse cholesterol transport pathway;79
10.5;Influence of alcohol consumption on the reverse cholesterol transport pathway;80
10.6;Influence of smoking on the reverse cholesterol transport pathway;81
10.7;Influence of postprandial state on the reverse cholesterol transport pathway;82
10.8;Conclusion;84
10.9;Acknowledgments;84
10.10;References;84
11;Chapter 5
Serum Paraoxonase (PON1) and its Interactions with HDL: Relationship between PON1 and Oxidative Stress;90
11.1;Introduction;90
11.2;HDL - structure, heterogeneity and anti-atherogenic properties;91
11.3;Paraoxonase-1 (PON1);95
11.4;The association between PON1 and HDL;96
11.5;Conclusion;105
11.6;References;105
12;Chapter 6
Paraoxonase-1 and its Interactions with HDL: Molecular Structures ofnbspPON1nbspand HDL;112
12.1;Introduction;112
12.2;PON1 as a promiscuous human plasma enzyme;115
12.3;HDL molecular environment of PON1;119
12.4;Impediments for studying the passenger PON1 andnbspthe vehicle HDL;121
12.5;PON1 activity in normal HDL conditions;125
12.6;PON1 activity in altered HDL conditions;128
12.7;PON1 activity in therapeutic HDL;131
12.8;Conclusion;134
12.9;References;135
13;Chapter 7
Apolipoprotein A-I Mutations;146
13.1;Introduction;146
13.2;GENOMIC AND PROTEIN STRUCTURE OF APOA-I;147
13.3;PHYSIOLOGICAL FUNCTIONS OF APOA-I;147
13.4;APOA-I DEFICIENCIES WITH LARGE DELETION, NONSENSE OR FRAMESHIFT MUTATIONS;148
13.5;APOLIPOPROTEIN A-I VARIANTS;152
13.6;REFERENCES;157
14;Chapter 8
The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling;166
14.1;Overview;166
14.2;Role of SR-BI in HDL metabolism, atherosclerosis and coronary heart disease - studies from genetically altered mice;166
14.3;SR-BI mediated HDL lipid uptake and efflux;168
14.4;Cellular Biology of SR-BI: Localization;169
14.5;SR-BI-mediated endocytosis of HDL;172
14.6;Multime