Laboratory Animal Medicine | E-Book | sack.de
E-Book

E-Book, Englisch, 769 Seiten

Laboratory Animal Medicine


E-Book, Englisch, 769 Seiten

ISBN: 978-1-4832-6916-0
Verlag: Elsevier Reference Monographs
Format: PDF
 Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals.
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1;Front Cover;1
2;Laboratory Animal Medicine;4
3;Copyright Page;5
4;Table of Contents;6
5;List of Contributors;10
6;Preface;12
7;List of Reviewers for Chapters in This Volume;14
8;Chapter 1. Laboratory Animal Medicine: Historical Perspectives;18
8.1;I. Introduction;18
8.2;II. Origins of Animal Experimentation;19
8.3;III. Early Veterinarians in Laboratory Animal Science and Medicine;21
8.4;IV. The Organizations of Laboratory Animal Science;24
8.5;V. Education and Training in Laboratory Animal Medicine;31
8.6;VI. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine;32
8.7;VII. Regulation of Animal Research in the United Kingdom and Canada;32
8.8;VIII. Commercial Rodent Breeding;33
8.9;IX. Conclusion;33
8.10;References;33
9;Chapter 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals;36
9.1;I. Introduction;36
9.2;II. Animal Welfare;37
9.3;III. Collection, Importation, Exportation, and Shipment of Animals;43
9.4;IV. Hazardous Substances;45
9.5;V. Good Laboratory Practices;46
9.6;References;46
10;Chapter 3. Biology and Diseases of Mice;48
10.1;I.Introduction;48
10.2;II. Biology;53
10.3;III. Diseases;61
10.4;References;105
11;Chapter 4. Biology and Diseases of Rats;108
11.1;I. Introduction;108
11.2;II. Biology;110
11.3;III. Diseases;116
11.4;References;137
12;Chapter 5. Biology and Diseases of Hamsters;140
12.1;Syrian Hamster;141
12.2;Chinese Hamster;157
12.3;European Hamster;160
12.4;Armenian Hamster;161
12.5;References;162
13;Chapter 6. Biology and Diseases of Guinea Pigs;166
13.1;I. Introduction;166
13.2;II. Biology;167
13.3;III. Diseases;175
13.4;References;194
14;Chapter 7. Biology and Diseases of Other Rodents;200
14.1;I. Introduction;200
14.2;II. Biology;207
14.3;III. Diseases;211
14.4;References;222
15;Chapter 8. Biology and Diseases of Rabbits;224
15.1;I. Introduction;224
15.2;II. Biology;226
15.3;III. Diseases;234
15.4;References;254
16;Chapter 9. Dogs and Cats as Laboratory Animals;258
16.1;I. Introduction;258
16.2;II. Types and Sources of Dogs and Cats;259
16.3;III. Housing;260
16.4;IV. Conditioning;261
16.5;V. Canine and Feline Breeding Colony Management;267
16.6;VI. Nutrition and Feeding;274
16.7;VII. Diseases;275
16.8;VIII. Selected Normative Data;284
16.9;References;285
17;Chapter 10. Ungulates as Laboratory Animals;290
17.1;I. Introduction;291
17.2;II. Taxonomy;291
17.3;III. General Comments and Examples of Use in Research;291
17.4;IV. Availability, Sources, and Acquisition;292
17.5;V. Evaluation of Incoming Animals;293
17.6;VI. Routine Health Maintenance;296
17.7;VII. Synchronization of Ovulation;296
17.8;VIII. Facilities;296
17.9;IX. Appendix;299
17.10;References;311
18;Chapter 11. Primates;314
18.1;Introduction;315
18.1.1;References;318
18.2;Part A. Biology and Diseases of Old World Primates;318
18.2.1;References;336
18.3;Part B. Biology and Diseases of Cebidae;338
18.3.1;References;367
18.4;Part C. Biology and Diseases of Callitrichidae;370
18.4.1;References;396
19;Chapter 12. Biology and Diseases of Ferrets;402
19.1;I. Introduction;403
19.2;II. Biology;403
19.3;III. Routine Veterinary Medical Care;406
19.4;IV. Infectious Diseases;406
19.5;V. Nutritional and Metabolic Diseases;411
19.6;VI. Neoplastic Diseases;413
19.7;References;413
20;Chapter 13. Biology and Diseases of Birds;416
20.1;I. Introduction;417
20.2;II. Biology;419
20.3;III. Diseases Caused by Bacteria;420
20.4;IV. Diseases Caused by Viruses;428
20.5;V. Diseases Caused by Parasites;433
20.6;VI. Diseases Caused by Fungi/Yeasts;437
20.7;VII. Diseases Resulting in Neoplastic Changes;438
20.8;VIII. Diseases Caused by Nutritional Deficiencies;439
20.9;Selected References;442
21;Chapter 14. Biology and Diseases of Amphibians;444
21.1;I. Introduction;444
21.2;II. Biology;444
21.3;III. Diseases;451
21.4;References;462
22;Chapter 15. Biology and Diseases of Reptiles;466
22.1;I. Introduction;466
22.2;II. Biology;469
22.3;III. Diseases;477
22.4;References;493
23;Chapter 16. Biology and Diseases of Fish;496
23.1;I. Introduction;496
23.2;II. Biology;498
23.3;III. Diseases;506
23.4;References;522
24;Chapter 17. Design and Management of Animal Facilities;524
24.1;I. Introduction;524
24.2;II. Facilities Design and Equipment;524
24.3;III. Management;540
24.4;IV. Conclusion;543
24.5;References;543
25;Chapter 18. Preanesthesia, Anesthesia, Analgesia, and Euthanasia;546
25.1;I. Introduction;547
25.2;II. Preanesthesia, Anesthesia, and Analgesia;547
25.3;III. Euthanasia;573
25.4;References;580
26;Chapter 19. Techniques of Experimentation;582
26.1;I. Introduction;583
26.2;II. Identification Methods;583
26.3;III. Blood Collection and Intravenous Injection;584
26.4;IV. Vascular Cannulation;588
26.5;V. Intraperitoneal Injection;588
26.6;VI. Subcutaneous and Intramuscular Injection;589
26.7;VII. Oral Administration of Substances;589
26.8;VIII. Digestive System;589
26.9;IX. Urinary Techniques;592
26.10;X. Respiratory System Techniques;594
26.11;XI. Reproductive System ;597
26.12;XII. Cardiovascular Techniques;600
26.13;XIII. Endocrine System Techniques;601
26.14;XIV. Orthopedic Procedures for Laboratory Animals;603
26.15;XV. Neurosurgical Techniques;603
26.16;XVI. Tumor Transplantation;606
26.17;References;607
27;Chapter 20. Control of Biohazards Associated with the Use of Experimental Animals;614
27.1;I. Introduction;614
27.2;II. The Infectious Process;615
27.3;III. Risk Assessment;616
27.4;IV. Biosafety Practices and Procedures;616
27.5;V. Summation;621
27.6;References;621
28;Chapter 21. Genetic Monitoring;622
28.1;I. Introduction;622
28.2;II. Sources of Genetic Impurity of Inbred Strains;623
28.3;III. Evidence of Genetic Contamination;624
28.4;IV. Methods of Genetic Monitoring;625
28.5;V. Summary;630
28.6;References;630
29;Chapter 22. Selected Zoonoses and Other Health Hazards;632
29.1;I. Introduction;633
29.2;II. Viral Diseases;633
29.3;III. Rickettsial and Chlamydial Diseases;640
29.4;IV. Bacterial Diseases;643
29.5;V. Mycoses;650
29.6;VI. Protozoan Diseases;652
29.7;VII. Helminth Infections;655
29.8;VIII. Arthropod Infestations;655
29.9;IX. Bites and Scratches;659
29.10;X. Allergic Sensitivities;661
29.11;XI. Conclusions;662
29.12;References;662
30;Chapter 23. Factors That Complicate Animal Research;668
30.1;I. Introduction;668
30.2;II. Physical Factors;669
30.3;III. Chemical Factors;671
30.4;IV. Microbial Factors;676
30.5;References;679
31;Chapter 24. Animal Models in Biomedicai Research;686
31.1;I. Introduction;686
31.2;II. History;687
31.3;III. Symposia;689
31.4;IV. Publications;690
31.5;V. Selection of Animals;690
31.6;VI. Selected Animal Models;691
31.7;References;707
31.8;Additional Books, Proceedings, and Bulletins;713
32;Chapter 25. Developing Research in Laboratory Animal/Comparative Medicine;716
32.1;I. Introduction;716
32.2;II. The Research Process;717
32.3;III. Training for Research in Laboratory Animal/Comparative Medicine;720
32.4;IV. Development of Research Resources;721
32.5;V. Support for Research;724
32.6;References;725
33;Chapter 26. Rodent and Lagomorph Health Surveillance—Quality Assurance;728
33.1;I. Introduction;728
33.2;II. Design of Quality Assurance Programs;729
33.3;III. Quarantine;738
33.4;IV. Conclusions;740
33.5;References;741
34;Index;744

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