Progress and Future Challenges
E-Book, Englisch, 746 Seiten, eBook
ISBN: 978-1-4419-0840-7
Verlag: Springer US
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Weitere Infos & Material
Section I: Determinants of Drug ADME
1. Enzymatic Basis Of Phase I And Phase II Drug Metabolism
2. Transporters: Importance In Drug Absorption, Distribution And Elimination
3. ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions
4. Impact Of Nuclear Receptors, CAR, PXR, FXR, And VDR, And Their Ligands On Enzymes And Transporters
5. Impact of Physiological Determinants: Flow, Binding, Transporters And Enzymes On Organ and Total Body Clearances
Section II: Methods For The Study Of Drug-Drug Interactions
6. In Silico Approaches to Predict Drug-Drug Interactions
7. In Vitro Techniques To Study Drug-Drug Interactions Of Drug Metabolism: Cytochrome P450
8. In Vitro Characterization Of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase
9. In Vitro Techniques To Study Transporter-Based Drug-Drug Interactions
10. In Vitro Techniques To Study Drug-Drug Interactions Involving Transport: Caco-2 Model For Study Of P-Glycoprotein And Other Transporters
11. Use Of In Vivo Animal Models To Assess Drug-Drug Interactions
12. Extrapolation of In Vitro Metabolic and P-Glycoprotein-mediated Transport Data To In Vivo By Modeling and Simulations
13. Translation Of In Vitro Metabolic Data To Predict In Vivo Drug-Drug Interactions: IVIVE And Modeling And Simulations
14. Absorption Models To Examine Bioavailability And DDI’s In Humans
15. Management Of Drug Interactions Of New Drugs In Multicenter Trials Using The Metabolism & Transport Drug Interaction Database©
16. Web-Based Database As A Tool To Examine Drug-Drug Interactions Involving Transporters
Section III: Impact Of Drug-Drug Interactions
17. Drug Disposition And Drug-Drug Interactions: Importance Of First-Pass Metabolism In Gut And Liver
18. Transporter Based Drug-Drug Interactions And Their Effect On Distribution Volumes
19. Inactivation Of Human Cytochrome P450Enzymes And Drug-Drug Interactions
20. Allosteric Enzyme And Transporter Based Interactions
21. Interplay Of Transporter-Drug Interaction: Complications Of Both Inhibitory And Inductive Events In Drug-Drug Interaction
22. Herbal Supplement-Based Interactions
23. Anticipating And Minimizing Drug Interactions In A Drug Discovery And Development Setting: Industrial Perspective
24. Clinical Studies Of Drug-Drug Interactions: Design And Interpretation
25. Toxicological Consequences Of Drug Drug Interactions
Section IV: Regulatory Aspects And Future Developments Involving DDI
26. Complex Drug Interactions: Significance And Evaluation
27. DDI: Labeling And Marketing Perspectives
28. Drug-Drug Interactions: What Have We Learnt And Where Are We Going?