E-Book, Englisch, 730 Seiten
ISBN: 978-0-12-386526-7
Verlag: Elsevier Reference Monographs
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
* Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience
* Provides key information about all aspects of autonomic physiology and pathology
* Discusses stress and how its effects on the body are mediated
* Compiles contributions by over 140 experts on the autonomic nervous system
Autoren/Hrsg.
Weitere Infos & Material
1;Front Cover;1
2;Primer on the Autonomic Nervous System;4
3;Copyright Page;5
4;Contents;6
5;Preface;20
6;List of Contributors;22
7;I. Introduction;28
7.1;1 Development and Differentiation of Autonomic Neurons;30
7.1.1;Introduction;30
7.1.2;The ANS is Derived from Neural Crest Cells;30
7.1.3;Signaling Molecules Regulate the Developmental Processes of the ANS;30
7.1.4;Transcriptional Regulatory Code Underlying the Development and Phenotypic Specification of the ANS;31
7.1.4.1;Mash1 (also called Cash1);31
7.1.4.2;Phox2 Genes;32
7.1.4.3;GATA3;32
7.1.4.4;AP2(Activator Protein 2)ß;32
7.1.4.5;Other Transcription Factors;33
7.1.5;Neurotransmitter Phenotypes of the ANS;33
7.1.5.1;NA Phenotype;33
7.1.5.2;Control Mechanism of DBH Gene Expression is Closely Related to the ANS Development;33
7.1.5.3;Mutations of DBH Gene are Closely Associated with the Autonomic Disorder, Orthostatic Hypotension;33
7.1.5.4;Cholinergic Phenotype and the Switch of Neurotransmitter Phenotypes by Target Cell Interactions;34
7.1.6;Acknowledgements;34
7.1.7;References;34
7.2;2 Central Autonomic Control;36
7.2.1;Forebrain Components;36
7.2.1.1;Insular Cortex;36
7.2.1.2;Anterior Cingulate Cortex;36
7.2.1.3;Amygdala;36
7.2.1.4;Hypothalamus;36
7.2.2;Brainstem Components;37
7.2.2.1;Periaqueductal Gray;37
7.2.2.2;Parabrachial Complex and Adjacent Regions of the Pons;38
7.2.2.3;Nucleus of the Solitary Tract;38
7.2.2.4;Rostral Ventrolateral Medulla;38
7.2.2.5;Caudal Ventrolateral Medulla;38
7.2.2.6;Ventromedial Medulla and Caudal Raphe;38
7.2.3;Autonomic Output of the Central Nervous System;38
7.2.3.1;Sympathetic Preganglionic Units;38
7.2.3.2;Parasympathetic Outputs;38
7.2.3.2.1;Vagal Output;39
7.2.3.2.2;Sacral Parasympathetic Output;39
7.2.4;References;39
7.3;3 Imaging of Brainstem Sites Involved in Cardiovascular Control;40
7.3.1;Identification of Medullary Cardiovascular Nuclei in Experimental Animals;40
7.3.2;Identification of Medullary Cardiovascular Nuclei in Humans;40
7.3.3;References;43
7.4;4 Peripheral Autonomic Nervous System;44
7.4.1;Sympathetic Nervous system (See Fig. 4.1);44
7.4.2;Sympathoadrenal Axis and the Adrenal Gland;47
7.4.3;Parasympathetic Nervous System (See Fig. 4.1);48
7.4.4;The Concept of Plurichemical Transmission and Chemical Coding;49
7.4.5;Visceral Afferent Neurons and Autonomic Nervous System;50
7.4.6;Functional Neuroanatomy and Biochemical Pharmacology;51
7.4.7;Stress and Autonomic Dysfunction;52
7.4.8;References;52
7.4.9;Further Reading;53
7.5;5 Cotransmission;54
7.5.1;Early Studies;54
7.5.2;Sympathetic Nerves;54
7.5.3;Parasympathetic Nerves;55
7.5.4;Sensory-Motor Nerves;56
7.5.5;Enteric and Cardiac Nerves;56
7.5.6;Physiological Significance of Cotransmission;57
7.5.6.1;Cotransmitters with Different Firing Patterns;57
7.5.6.2;Different Cotransmitters act on Different Postjunctional Cells;57
7.5.6.3;Neuromodulation;57
7.5.6.4;Synergism;58
7.5.6.5;Negative Cross-Talk;59
7.5.6.6;Trophic Factors;59
7.5.6.7;Excitatory and Inhibitory Cotransmitters;59
7.5.6.8;False Cotransmitters;59
7.5.6.9;Coexisting Peptides Acting as Neuromodulators;59
7.5.7;Cotransmitter Plasticity;59
7.5.8;Concluding Comments;59
7.5.9;References;60
8;II. Biochemical and Pharmacological Mechanisms;62
8.1;6 Noradrenergic Neurotransmission;64
8.1.1;Catecholamines, and Catechols;64
8.1.2;Noradrenergic Innervation of the Cardiovascular System;64
8.1.3;Norepinephrine: the Main Sympathetic Cardiovascular Neurotransmitter;65
8.1.3.1;Norepinephrine Synthesis;65
8.1.3.2;Norepinephrine Storage;65
8.1.3.3;Norepinephrine Release;66
8.1.3.4;Norepinephrine Disposition;66
8.1.3.5;Norepinephrine Metabolism;68
8.1.4;Biomarkers of Sympathetic Noradrenergic Innervation and Function;69
8.1.5;NE and Metabolomics;69
8.1.6;Differential Noradrenergic vs. Adrenergic Activation in Stress;69
8.1.7;Further reading;70
8.2;7 Tyrosine Hydroxylase;72
8.2.1;Introduction;72
8.2.2;Diversity of Human TH Gene Expression;72
8.2.3;Congenital Disease Associated with TH Mutation;73
8.2.4;Gene Therapy with TH Ge