Vance Biochemistry of Lipids, Lipoproteins and Membranes

5. Auflage 2008
ISBN: 978-0-08-055988-9
Verlag: Elsevier Reference Monographs
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 624 Seiten

Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.
Key Features:
* Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs.
* Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances.
* Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry.

Autoren/Hrsg.

Vance, J.E.

Inhaltsverzeichnis

1;Cover;1
2;Preface;6
3;List of contributors;8
4;Contents;12
5;Chapter 1. Functional roles of lipids in membranes;14
5.1;1. Introduction and overview;15
5.2;2. Diversity in lipid structure;16
5.3;3. Properties of lipids in solution;20
5.4;4. Engineering of membrane lipid composition;27
5.5;5. Role of lipids in cell function;30
5.6;6. Summary and future directions;48
5.7;Abbreviations;49
5.8;References;49
6;Chapter 2. Lipid modifications of proteins;52
6.1;1. Introduction;52
6.2;2. Protein prenylation;54
6.3;3. Fatty acylation of proteins: N-myristoylation;56
6.4;4. Fatty acylation of proteins: S-acylation;57
6.5;5. Membrane anchoring of fatty acylated and prenylated proteins: the two-signal hypothesis, lipid switches, and dynamic acylation;59
6.6;6. Membrane targeting and intracellular trafficking of fatty acylated and prenylated proteins;61
6.7;7. Lipid modifications of secreted proteins: Hedgehog, Wingless/ Wnt, and Spitz;62
6.8;8. GPI anchoring of proteins;64
6.9;9. Future directions;69
6.10;Abbreviations;70
6.11;References;70
7;Chapter 3. Fatty acid and phospholipid metabolism in prokaryotes;72
7.1;1. Bacterial lipid metabolism;73
7.2;2. Membrane systems of bacteria;76
7.3;3. Bacterial fatty acid biosynthesis;77
7.4;4. Transfer to the membrane;84
7.5;5. Phospholipid biosynthesis;85
7.6;6. Lipid A biosynthesis;90
7.7;7. Phospholipid flippase;92
7.8;8. Degradation of fatty acids and phospholipids;93
7.9;9. Phospholipid turnover;97
7.10;10. Regulation of lipid metabolism;99
7.11;11. Lipid metabolism in other bacteria;103
7.12;12. Inhibitors of lipid metabolism;106
7.13;13. Future directions;107
7.14;Abbreviations;107
7.15;References;108
8;Chapter 4. Lipid metabolism in plants;110
8.1;1. Introduction;111
8.2;2. Plant lipid geography;112
8.3;3. Acyl-ACP synthesis in plants;114
8.4;4. Acetyl-CoA carboxylase and control of fatty acid synthesis;117
8.5;5. Phosphatidic acid synthesis: 'prokaryotic' and 'eukaryotic' acyltransferases;117
8.6;6. Glycerolipid biosynthetic pathways;120
8.7;7. Lipid storage in plants;122
8.8;8. Protective lipids: cutin, suberin, and waxes;126
8.9;9. Sterol, isoprenoid, and sphingolipid biosynthesis;128
8.10;10. Oxylipins as plant hormones;129
8.11;11. Progress in plant lipid research: the value of mutants;131
8.12;12. Design of new plant oils;135
8.13;13. Future prospects;140
8.14;Abbreviations;141
8.15;References;142
9;Chapter 5. Oxidation of fatty acids in eukaryotes;144
9.1;1. The pathway of -oxidation: a historical account;144
9.2;2. Uptake and activation of fatty acids in animal cells;145
9.3;3. Fatty acid oxidation in mitochondria;147
9.4;4. Fatty acid oxidation in peroxisomes;159
9.5;5. Inherited diseases of fatty acid oxidation;164
9.6;6. Future directions;165
9.7;Abbreviations;166
9.8;References;166
10;Chapter 6. Fatty acid synthesis in eukaryotes;168
10.1;1. Introduction;169
10.2;2. Acetyl-CoA carboxylase;170
10.3;3. The cytosolic fatty acid synthase;173
10.4;4. The mitochondrial FAS;183
10.5;5. Regulation of fatty acid synthesis;184
10.6;6. Long-term regulation of fatty acid synthesis;192
10.7;7. Future directions;200
10.8;Abbreviations;201
10.9;References;201
11;Chapter 7. Fatty acid desaturation and chain elongation in mammals;204
11.1;1. Introduction;204
11.2;2. Elongation reactions of long-chain fatty acids;206
11.3;3. Desaturation of long-chain fatty acid in mammals;211
11.4;4. Functions of fatty acids synthesized by .9, .6, and .5 desaturases;216
11.5;5. Transcriptional regulation of desaturases and elongases;218
11.6;6. Summary and future directions;222
11.7;Abbreviations;222
11.8;References;223
12;Chapter 8. Phospholipid biosynthesis in eukaryotes;226
12.1;1. Introduction;227
12.2;2. Phosphatidic acid biosynthesis and conversion to diacylglycerol;227
12.3;3. Phosphatidylcholine biosynthesis;231
12.4;4. Regulation of phosphatidylcholine biosynthesis;237
12.5;5. Phosphatidylethanolamine biosynthesis;241
12.6;6. Phosphatidylserine biosynthesis;245
12.7;7. Inositol phospholipids;248
12.8;