E-Book, Englisch, 478 Seiten, eBook
E-Book, Englisch, 478 Seiten, eBook
Reihe: Stem Cell Biology and Regenerative Medicine
ISBN: 978-1-61779-246-5
Verlag: Humana Press
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)
represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.
Topics covered include:Introduction of the CSC hypothesisHistorical perspectives and the contributing lessons from leukemiaCurrent knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathwaysIn vitro
and
in vivo
assays, model systems, and imaging modalities for studying CSCs
The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistanceConsideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Weitere Infos & Material
Cancer Stem Cells: Historical Perspectives and Lessons From Leukemia.- Cancer Stem Cells in Breast Cancer.- Cancer Stem Cells in Brain Cancer.- Cancer Stem Cells in Colorectal Cancer.- Cancer Stem Cells in Pancreatic Cancer.- Cancer Stem Cells in Prostate Cancer.- Cancer Stem Cells in Melanoma.- Cancer Stem Cells in Lung Cancer.- Cancer Stem Cells in Ovarian Cancer.- Cancer Stem Cells in Hepatocellular Cancer.- Cancer Stem Cells in Head and Neck Cancer.- Relationship Between Regulatory Pathways in Pluripotent Stem Cells and Human Tumors.- Influence of the Embryonic Microenvironment on Tumor Progression.- The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells.- Application of Stem Cell Assays for the Characterization of Cancer Stem Cells.- Zebrafish as a Model to Study Stem Cells in Development, Disease and Cancer.- Imaging Cancer Stem Cells.- Mouse Models for Studying Normal and Cancer Stem Cells.- Cancer Stem Cells and Disease Prognosis.- Mechanisms of Radioresistance in Cancer Stem Cells.- The Role of ABC Transporters in Cancer Stem Cell Drug Resistance.- Resistance to Endocrine Therapy in Breast Cancer: Are Breast Cancer Stem Cells Implicated?.- Future Directions: Cancer Stem Cells as Therapeutic Targets.- Final Thoughts: Complexity and Controversy Surrounding the “Cancer Stem Cell” Paradigm.